Systems Virology Journal Club
The Systems Virology Journal club aims to bring together researchers interested in fundamental questions in virology and to introduce new methodologies and concepts in the field.
Registration (free): https://forms.gle/edTyLwR8jWkhrRWw9
Organizers
Running Series (2023/24)
10/19 Felix Horns, Michael Elowitz lab, Caltech/HHMI
Engineering RNA export for measurement and manipulation of living cells
11/16 Anna Sherwood, Jeppe Vinther lab, U. of Copenhagen
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide
12/14 Luka Mesin, Gabriel Victora lab, Rockefeller University
1/18 Rebecca Carlson, Paul Blainey and Nir Hacohen labs, Broad Institute
A genome-wide optical pooled screen reveals regulators of cellular antiviral responses
2/15 Akos Nyerges, George Church lab, Harvard
A swapped genetic code prevents viral infections and gene transfer
3/21 Della Fixsen, Nels Elde lab, U. of Utah/HHMI
Poxviruses capture host genes by LINE-1 retrotransposition
4/18 Jenny Seo, Narry Kim lab, Seoul National University
Functional viromic screens uncover regulatory RNA elements
5/16 Sonya Widen, Alejandro Burga lab, IMBA, Vienna BioCenter
Past Series
Fall 2020
9/24 Tyler Starr, Jesse Bloom lab, Fred Hutch
Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
10/8 Sonali Chaturvedi, Leor Weinberger lab, UCSF
A molecular mechanism for probabilistic bet hedging and its role in viral latency
10/22 Marco Hein, Jonathan Weissman lab, UCSF
Functional single-cell genomics of human cytomegalovirus infection
11/5 Tomasz Kula, Steve Elledge lab, Harvard
T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes
11/19 Molly OhAinle, Michael Emerman lab, Fred Hutch
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
12/3 Lea Meyer, Edward Hutchinson lab, University of Glasgow
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
12/17 Gonzalo Moratorio, Marco Vignuzzi lab, Institut Pasteur
Attenuation of RNA viruses by redirecting their evolution in sequence space
1/7 Laura Murray-Nerger, Ileana Cristea lab, Princeton
Orchestration of protein acetylation as a toggle for cellular defense and virus replication
Spring 2021
3/11 Sanne Boersma, Marvin Tanenbaum lab, Hubrecht Institute
Translation and Replication Dynamics of Single RNA Viruses
3/25 Pierce Ogden, George Church lab, Harvard University
Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
4/8 Caroline Atyeo, Galit Alter lab, Harvard University
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival
4/15 Michel Tassetto, Raul Andino lab, UCSF
Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements
4/29 Mohsan Saeed, Charlie Rice lab, Rockefeller University
Defining the proteolytic landscape during enterovirus infection
5/13 Louis du Plessis, Oliver Pybus lab, University of Oxford
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK
5/27 Delphine Planas, Olivier Schwartz lab, Institut Pasteur
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies
6/10 Agnes Karasik, Nicholas Guydosh lab, NIH/NIDDK
Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences
Fall 2021
9/23 Michael Segel, Feng Zhang lab, Broad Institute
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery
10/7 Sizun Jiang, Garry Nolan lab, Stanford University
Virus-Dependent Immune Conditioning of Tissue Microenvironments
10/21 Yaara Finkel, Noam Stern-Ginossar lab, Weizmann Institute
SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis
10/28 Zak Singer, Tal Danino & Charlie Rice labs, Columbia and Rockefeller Universities
Quantitative measurements of early alphaviral replication dynamics in single cells reveals the basis for superinfection exclusion
11/18 Livia Victoria Patrono, Sébastien Calvignac-Spencer lab, Robert Koch Institute
Archival influenza virus genomes from Europe reveal genomic and phenotypic variability during the 1918 pandemic
12/9 Sarah Arcos, Manny Ascano lab, Vanderbilt University
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP
Spring 2022
3/31 Adi Millman, Rotem Sorek lab, Weizmann Institute
Bacterial Retrons Function In Anti-Phage Defense
4/14 Connor Dobson, Michael Birnbaum lab, MIT
Antigen identification and high-throughput interaction mapping by reprogramming viral entry
4/28 Jeannette Tenthorey, Harmit Malik lab, Fred Hutch
Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
5/12 Ben Nilsson-Payant, Ben tenOever lab, NYU
Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition
5/26 Justin English, Bryan Roth lab, UNC
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
6/9 Lara Rheinemann, Wes Sundquist and Nels Elde labs, University of Utah
RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis
Fall 2022
9/29 Arti Navare, John Aitchison lab, at Seattle Children’s Research Institute
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality
10/13 Valeria Lulla, Andrew Firth lab, University of Cambridge
A hidden gene in astroviruses encodes a viroporin
10/20 Isaque Faria, João Marques lab, University of Minas Gerais
Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila
11/10 Silvia Groiss, Kurt Zatloukal lab, University of Graz
Highly resolved spatial transcriptomics for detection of rare events in cells
11/17 Cecile King, Cecile King lab, University of New South Wales Sydney
The retroelement Lx9 puts a brake on the immune response to virus infection
12/15 Arpiar Saunders, Steven McCarroll lab, Harvard
Ascertaining cells’ synaptic connections and RNA expression simultaneously with massively barcoded rabies virus libraries