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Systems Virology Journal Club

The Systems Virology Journal club aims to bring together researchers interested in fundamental questions in virology and to introduce new methodologies and concepts in the field.


Registration (free): 

Covid 19


Running Series (2023/24)

10/19 Felix Horns, Michael Elowitz lab, Caltech/HHMI

Engineering RNA export for measurement and manipulation of living cells

11/16 Anna Sherwood, Jeppe Vinther lab, U. of Copenhagen

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide

12/14 Luka Mesin, Gabriel Victora lab, Rockefeller University

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

1/18 Rebecca Carlson, Paul Blainey and Nir Hacohen labs, Broad Institute

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

2/15 Akos Nyerges, George Church lab, Harvard

A swapped genetic code prevents viral infections and gene transfer

3/21 Della Fixsen, Nels Elde lab, U. of Utah/HHMI

Poxviruses capture host genes by LINE-1 retrotransposition

4/18 Jenny Seo, Narry Kim lab, Seoul National University

Functional viromic screens uncover regulatory RNA elements

5/16 Sonya Widen, Alejandro Burga lab, IMBA, Vienna BioCenter

Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibilities

Past Series

Fall 2020

9/24 Tyler Starr, Jesse Bloom lab, Fred Hutch

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

10/8 Sonali Chaturvedi, Leor Weinberger lab, UCSF

A molecular mechanism for probabilistic bet hedging and its role in viral latency

10/22 Marco Hein, Jonathan Weissman lab, UCSF

Functional single-cell genomics of human cytomegalovirus infection

11/5 Tomasz Kula, Steve Elledge lab, Harvard

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes

11/19 Molly OhAinle, Michael Emerman lab, Fred Hutch

A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

12/3 Lea Meyer, Edward Hutchinson lab, University of Glasgow

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

12/17 Gonzalo Moratorio, Marco Vignuzzi lab, Institut Pasteur

Attenuation of RNA viruses by redirecting their evolution in sequence space

1/7 Laura Murray-Nerger, Ileana Cristea lab, Princeton

Orchestration of protein acetylation as a toggle for cellular defense and virus replication

Spring 2021

3/11 Sanne Boersma, Marvin Tanenbaum lab, Hubrecht Institute

Translation and Replication Dynamics of Single RNA Viruses

3/25 Pierce Ogden, George Church lab, Harvard University

Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design

4/8 Caroline Atyeo, Galit Alter lab, Harvard University

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival

4/15 Michel Tassetto, Raul Andino lab, UCSF

Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

4/29 Mohsan Saeed, Charlie Rice lab, Rockefeller University

Defining the proteolytic landscape during enterovirus infection

5/13 Louis du Plessis, Oliver Pybus lab, University of Oxford

Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK

5/27 Delphine Planas, Olivier Schwartz lab, Institut Pasteur

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

6/10 Agnes Karasik, Nicholas Guydosh lab, NIH/NIDDK

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences

Fall 2021

9/23 Michael Segel, Feng Zhang lab, Broad Institute

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

10/7 Sizun Jiang, Garry Nolan lab, Stanford University

Virus-Dependent Immune Conditioning of Tissue Microenvironments

10/21 Yaara Finkel, Noam Stern-Ginossar lab, Weizmann Institute

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

10/28 Zak Singer, Tal Danino & Charlie Rice labs, Columbia and Rockefeller Universities

Quantitative measurements of early alphaviral replication dynamics in single cells reveals the basis for superinfection exclusion

11/18 Livia Victoria Patrono, Sébastien Calvignac-Spencer lab, Robert Koch Institute

Archival influenza virus genomes from Europe reveal genomic and phenotypic variability during the 1918 pandemic

12/9 Sarah Arcos, Manny Ascano lab, Vanderbilt University

Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP

Spring 2022

3/31 Adi Millman, Rotem Sorek lab, Weizmann Institute

Bacterial Retrons Function In Anti-Phage Defense

4/14 Connor Dobson, Michael Birnbaum lab, MIT

Antigen identification and high-throughput interaction mapping by reprogramming viral entry

4/28 Jeannette Tenthorey, Harmit Malik lab, Fred Hutch

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

5/12 Ben Nilsson-Payant, Ben tenOever lab, NYU

Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition

5/26 Justin English, Bryan Roth lab, UNC

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells

6/9 Lara Rheinemann, Wes Sundquist and Nels Elde labs, University of Utah

RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis

Fall 2022

9/29 Arti Navare, John Aitchison lab, at Seattle Children’s Research Institute

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality


10/13 Valeria Lulla, Andrew Firth lab, University of Cambridge

A hidden gene in astroviruses encodes a viroporin

10/20 Isaque Faria, João Marques lab, University of Minas Gerais

Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila

11/10 Silvia Groiss, Kurt Zatloukal lab, University of Graz

Highly resolved spatial transcriptomics for detection of rare events in cells

11/17 Cecile King, Cecile King lab, University of New South Wales Sydney

The retroelement Lx9 puts a brake on the immune response to virus infection

12/15 Arpiar Saunders, Steven McCarroll lab, Harvard

Ascertaining cells’ synaptic connections and RNA expression simultaneously with massively barcoded rabies virus libraries

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